Serlin 50 Drug Interactions

Sertraline may increase the levels/effects of selected beta-blockers, bupropion, selected benzodiazepines, calcium channel blockers, cisapride, cyclosporine, dextromethorphan, ergot alkaloids, fluoxetine, paroxetine, phenytoin, risperidone, selegiline and sildenafil.
The levels/effects of sertraline may be increased by chlorpromazine, fluconazole, fluoxetine, fluvoxamine, gemfibrozil, isoniazid, miconazole, omeprazole, quinine and ticlopidine.
Combined use of sertraline and buspirone, nefazodone, serotonin agonists (such as sumatriptan), ritonavir, tramadol and venlafaxine may increase the risk of serotonin syndrome.
Concurrent lithium may increase risk of nephrotoxicity.
Risk of hyponatremia may increase with concurrent use of loop diuretics (bumetanide, furosemide, torsemide).
Co-administration of sertraline with warfarin results in small but significant increase in prothrombin time, prothrombin time should be carefully monitored in such cases.
Although sertraline did not potentiate the cognitive and psychomotor effects of alcohol in normal subjects, the concomitant use of this drug and alcohol in depressed patients is not recommended.
No interaction was observed with digoxin.
Concomitant use of sertraline and NSAIDs, aspirin, or other drug affecting coagulation has been associated with an increased risk of bleeding.
Sertraline may inhibit the metabolism of thioridazine or mesoridazine, resulting in increased plasma levels and increasing the risk of QTc interval prolongation. This may lead to serious ventricular arrhythmias.
The levels/effects of sertraline may be decreased by aminoglutethimide, carbamazepine, phenytoin, rifampin.